We report herein the design and synthesis of a series of novel 5-bromo-7-azaindolin-2-one\nderivatives containing a 2,4-dimethyl-1H-pyrrole-3-carboxamide moiety. These newly synthesized\nderivatives were evaluated for in vitro activity against selected cancer cell lines by MTT assay. Results\nrevealed that some compounds exhibit broad-spectrum antitumor potency, and the most active\ncompound 23p (IC50: 2.357ââ?¬â??3.012 Ã?¼M) was found more potent than Sunitinib (IC50: 31.594ââ?¬â??49.036 Ã?¼M)\nagainst HepG2, A549 and Skov-3, respectively.
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